Human Infectious Disease

Generation of a humanized mouse model with both human immune system and liver cells to model hepatitis C virus infection and liver immunopathogenesis. Bility MT, Zhang L, Washburn ML, Curtis TA, Kovalev GI, Su L. Nat Protoc. 2012 Sep;7(9):1608-17. doi: 10.1038/nprot.2012.083. Epub 2012 Aug 9. PMID: 22899330

Leishmania major infection in humanized mice induces systemic infection and provokes a nonprotective human immune response.  Wege AK, Florian C, Ernst W, Zimara N, Schleicher U, Hanses F, Schmid M, Ritter U. PLoS Negl Trop Dis. 2012;6(7):e1741. doi: 10.1371/journal.pntd.0001741. Epub 2012 Jul 24. PMID: 22848771

Enhanced humoral and hla-a2-restricted dengue virus-specific t cell responses in humanized blt nsg mice. Jaiswal S, Pazoles P, Woda M, Shultz LD, Greiner DL, Brehm MA, Mathew A.  Immunology. 2012 Jul;136(3):334-43. doi: 10.1111/j.1365-2567.2012.03585.x.  PMID: 22384859

An Epstein-Barr virus (EBV) mutant with enhanced BZLF1 expression causes lymphomas with abortive lytic EBV infection in a humanized mouse model.  Ma SD, Yu X, Mertz JE, Gumperz JE, Reinheim E, Zhou Y, Tang W, Burlingham WJ, Gulley ML, Kenney SC.  J Virol. 2012 May 23. [Epub ahead of print]  PMID: 22623780
 
Mosquito bite delivery of dengue virus enhances immunogenicity and pathogenesis in humanized mice.  Cox J, Mota J, Sukupolvi-Petty S, Diamond MS, Rico-Hesse R.
J Virol. 2012 May 9. [Epub ahead of print]  PMID: 22573866

Animal models for the study of hepatitis C virus infection and related liver disease.  Bukh J. Gastroenterology. 2012 May;142(6):1279-1287.e3. Review. PMID: 22537434

Deconstructing hepatitis C virus infection in humanized mice.  Dorner M, Ploss A.  Ann N Y Acad Sci. 2011 Dec;1245:59-62. doi: 10.1111/j.1749-6632.2011.06317.x.  PMID: 22211981

A novel animal model of Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis in humanized mice.  Sato K, Misawa N, Nie C, Satou Y, Iwakiri D, Matsuoka M, Takahashi R, Kuzushima K, Ito M, Takada K, Koyanagi Y.  Blood. 2011 May 26;117(21):5663-73. Epub 2011 Apr 5.  PMID: 21467545

Further improvements of the P. falciparum humanized mouse model.  Arnold L, Tyagi RK, Meija P, Swetman C, Gleeson J, Pérignon JL, Druilhe P.  PLoS One. 2011 Mar 31;6(3):e18045.  PMID: 21483851

HIV Pathogenesis

A mouse model for HIV-1 entry. Pietzsch J, Gruell H, Bournazos S, Donovan BM, Klein F, Diskin R, Seaman MS, Bjorkman PJ, Ravetch JV, Ploss A, Nussenzweig MC. Proc Natl Acad Sci U S A. 2012 Sep 25;109(39):15859-64. Epub 2012 Sep 10. PMID: 23019371

Effective elicitation of human effector CD8+ T Cells in HLA-B*51:01 transgenic humanized mice after infection with HIV-1. Sato Y, Nagata S, Takiguchi M. PLoS One. 2012;7(8):e42776. doi: 10.1371/journal.pone.0042776. Epub 2012 Aug 6. PMID: 22880104

Rapid Evolution of HIV-1 to Functional CD8+ T cell Responses in Humanized BLT Mice.  Dudek TE, No DC, Seung E, Vrbanac VD, et al.  Sci Transl Med. 2012 Jul 18;4(143):143ra98  PMID: 22814851

Humanized mouse models of HIV-1 latency.  Duyne RV, Narayanan A, Kehn-Hall K, Saifuddin M, Shultz L, Kashanchi F.  Curr HIV Res. 2011 Dec 30. [Epub ahead of print]  PMID: 22211664

Alpha Interferon and HIV Infection Cause Activation of Human T Cells in NSG-BLT Mice.  Long BR, Stoddart CA.  J Virol. 2012 Mar;86(6):3327-36. Epub 2012 Jan 11.  PMID: 22238321

Superior human leukocyte reconstitution and susceptibility to vaginal HIV transmission in humanized NOD-scid IL-2R_(-/-) (NSG) BLT mice.  Stoddart CA, Maidji E, Galkina SA, Kosikova G, Rivera JM, Moreno ME, Sloan B, Joshi P, Long BR. Virology. 2011 Aug 15;417(1):154-60.  PMID: 21684569, PMCID: PMC3152643

HIV Therapeutics

In Vivo Blockade of the PD-1 Receptor Suppresses HIV-1 Viral Loads and Improves CD4+ T Cell Levels in Humanized Mice. Palmer BE, Neff CP, Lecureux J, Ehler A, Dsouza M, Remling-Mulder L, Korman AJ, Fontenot AP, Akkina R. J Immunol. 2012 Dec 3. PMID: 23209326

HIV therapy by a combination of broadly neutralizing antibodies in humanized mice.
Klein F, Halper-Stromberg A, Horwitz JA, Gruell H, Scheid JF, Bournazos S, Mouquet H, Spatz LA, Diskin R, Abadir A, Zang T, Dorner M, Billerbeck E, Labitt RN, Gaebler C, Marcovecchio PM, Incesu RB, Eisenreich TR, Bieniasz PD, Seaman MS, Bjorkman PJ, Ravetch JV, Ploss A, Nussenzweig MC. Nature. 2012 Dec 4;492(7427):118-22. doi: 10.1038/nature11604. Epub 2012 Oct 24. PMID: 23103874

Inhibitory effect of HIV-specific neutralizing IgA on mucosal transmission of HIV in humanized mice. Hur EM, Patel SN, Shimizu S, Rao DS, Gnanapragasam PN, An DS, Yang L, Baltimore D. Blood. 2012 Nov 29;120(23):4571-82. doi: 10.1182/blood-2012-04-422303. Epub 2012 Oct 11. PMID: 23065154

Topical gel formation of broadly neutralizing anti-HIV-1 monoclonal antibody VRC01 confers protection against HIV-1 vaginal challenge in a humanized mouse model.  Veselinovic M, Preston NC, Mulder LR, Akkina R.  Virology. 2012 Oct 25;432(2):505-10. Epub 2012 Jul 24.  PMID:22832125

An Improved Protocol for Efficient Engraftment in NOD/LTSZ-SCIDIL-2R?(NULL) Mice Allows HIV Replication and Development of Anti-HIV Immune Responses. Singh M, Singh P, Gaudray G, Musumeci L, Thielen C, Vaira D, Vandergeeten C, Delacroix L, Van Gulck E, Vanham G, de Leval L, Rahmouni S, Moutschen M. PLoS One. 2012;7(6):e38491. Epub 2012 Jun 4. PMID: 22675567

Mucosal HIV-1 transmission and prevention strategies in BLT humanized mice.
Denton PW, Garcia JV.  Trends Microbiol. 2012 Jun;20(6):268-74. Epub 2012 Apr 12.
PMID: 22503637

Generation of an HIV-1 resistant immune system with CD34+ HSCs transduced with a triple combination anti-HIV lentiviral vector.  Walker JE, Chen RX, McGee J, Nacey C, Pollard RB, Abedi M, Bauer G, Nolta JA, Anderson JS.  J Virol. 2012 Mar 7. [Epub ahead of print]  PMID: 22398281.

Liver X receptor agonist inhibits HIV-1 replication and prevents HIV-induced reduction of plasma HDL in humanized mouse model of HIV infection.  Dubrovsky L, Duyne RV, Senina S, Guendel I, Pushkarsky T, Sviridov D, Kashanchi F, Bukrinsky M.  Biochem Biophys Res Commun. 2012 Mar 2;419(1):95-8. Epub 2012 Feb 4.  PMID: 22326260

One Percent Tenofovir Applied Topically to Humanized BLT Mice and Used According to the CAPRISA 004 Experimental Design Demonstrates Partial Protection from Vaginal HIV Infection, Validating the BLT Model for Evaluation of New Microbicide Candidates.  Denton PW, Othieno F, Martinez-Torres F, Zou W, Krisko JF, Fleming E, Zein S, Powell DA, Wahl A, Kwak YT, Welch BD, Kay MS, Payne DA, Gallay P, Appella E, Estes JD, Lu M, Garcia JV.  J Virol. 2011 Aug;85(15):7582-93.  PMID: 21593172, PMCID: PMC3147928

Oral pre-exposure prophylaxis by anti-retrovirals raltegravir and maraviroc protects   against HIV-1 vaginal transmission in a humanized mouse model.  Neff CP, Ndolo T, Tandon A, Habu Y, Akkina R.  PLoS One. 2010 Dec 21;5(12):e15257.  PMID:  21203568