Human immune system development

Systemic Human T Cell Developmental Processes in Humanized Mice Cotransplanted With Human Fetal Thymus/Liver Tissue and Hematopoietic Stem Cells. Joo SY, Chung YS, Choi B, Kim M, Kim JH, Jun TG, Chang J, Sprent J, Surh CD, Joh JW, Kim SJ. Transplantation. 2012 Dec 15;94(11):1095-1102. PMID: 23222735

GM-CSF and IL-4 Stimulate Antibody Responses in Humanized Mice by Promoting T, B, and Dendritic Cell Maturation. Chen Q, He F, Kwang J, Chan JK, Chen J.
J Immunol. 2012 Dec 1;189(11):5223-9. doi: 10.4049/jimmunol.1201789. Epub 2012 Oct 22. PMID: 23089398

Comparison of three humanized mouse models for adoptive T cell transfer. Volk A, Hartmann S, Muik A, Geiss Y, Königs C, Dietrich U, von Laer D, Kimpel J.
J Gene Med. 2012 Aug;14(8):540-8. doi: 10.1002/jgm.2652. PMID: 22847974

Human B-cell ontogeny in humanized NOD/SCID gcnull mice generates a diverse yet auto/poly- and HIV-1 reactive antibody repertoire. Chang H, Biswas S, Tallarico AS, Sarkis PTN, Geng S, Panditrao MM, Zhu Q, Marasco WA.  Genes and Immunity.  (17 May 2012) | doi:10.1038/gene.2012.16 PMID: 22592523

EBNA3B-deficient EBV promotes B cell lymphomagenesis in humanized mice and is found in human tumors.  White RE, Rämer PC, Naresh KN, Meixlsperger S, Pinaud L, Rooney C, Savoldo B, Coutinho R, Bödör C, Gribben J, Ibrahim HA, Bower M, Nourse JP, Gandhi MK, Middeldorp J, Cader FZ, Murray P, Münz C, Allday MJ.  J Clin Invest. 2012 Mar 12. pii: 58092. doi: 10.1172/JCI58092. [Epub ahead of print]  PMID: 22406538

Characterization of human B cells in umbilical cord blood-transplanted NOD/SCID mice.  Wang X, Qi Z, Wei H, Tian Z, Sun R.  Transpl Immunol. 2012 Mar;26(2-3):156-62. Epub 2011 Dec 14.  PMID: 22198522

IL-15 transpresentation promotes both human T-cell reconstitution and T-cell-dependent antibody responses in vivo.  Huntington ND, Alves NL, Legrand N, Lim A, Strick-Marchand H, Mention JJ, Plet A, Weijer K, Jacques Y, Becker PD, Guzman C, Soussan P, Kremsdorf D, Spits H, Di Santo JP. Proc Natl Acad Sci U S A. 2011 Apr 12;108(15):6217-22.  PMID: 21444793, PMCID: PMC3076818

Human T cell development in the liver of humanized NOD/SCID/IL-2R_(null)(NSG) mice generated by intrahepatic injection of CD34(+) human (h) cord blood (CB) cells.  Choi B, Chun E, Kim M, Kim SY, Kim ST, Yoon K, Lee KY, Kim SJ.  Clin Immunol. 2011 Jun;139(3):321-35. doi: 10.1016/j.clim.2011.02.019. Epub 2011 Mar 2.  PMID: 21429805

Differential Secondary Reconstitution of In Vivo-Selected Human SCID-Repopulating Cells in NOD/SCID versus NOD/SCID/_ chain Mice.  Cai S, Wang H, Bailey B, Hartwell JR, Silver JM, Juliar BE, Sinn AL, Baluyut AR, Pollok KE.  Bone Marrow Res. 2011;2011:252953. Epub 2010 Dec 26.  PMID: 22046557

Generation of human antigen-specific monoclonal IgM antibodies using vaccinated "human immune system" mice.  Becker PD, Legrand N, van Geelen CM, Noerder M, Huntington ND, Lim A, Yasuda E, Diehl SA, Scheeren FA, Ott M, Weijer K, Wedemeyer H, Di Santo JP, Beaumont T, Guzman CA, Spits H. PLoS One. 2010 Oct 4;5(10). pii: e13137.  PMID: 20957227, PMCID: PMC2949385

Creation of "humanized" mice to study human immunity.  Pearson T, Greiner DL, Shultz LD.  Curr Protoc Immunol. 2008 May;Chapter 15:Unit 15.21.  PMID: 18491294