Cancer models/tumor immunotherapy

GANT-61 inhibits pancreatic cancer stem cell growth in vitro and in NOD/SCID/IL2R ? null mice xenograft. Fu J, Rodova M, Roy SK, Sharma J, Singh KP, Srivastava RK, Shankar S. Cancer Lett. 2012 Nov 28. doi:pii: S0304-3835(12)00665-9. 10.1016/j.canlet.2012.11.018. PMID: 23200667

Cytotoxic Capacity of IL-15-Stimulated Cytokine-Induced Killer Cells Against Human Acute Myeloid Leukemia and Rhabdomyosarcoma in Humanized Preclinical Mouse Models.  Rettinger E, Meyer V, Kreyenberg H, Volk A, Kuçi S, Willasch A, Koscielniak E, Fulda S, Wels WS, Boenig H, Klingebiel T, Bader P.  Front Oncol. 2012;2:32. Epub 2012 Apr 9. PMID: 22655268

Humanized mouse model of ovarian cancer recapitulates patient solid tumor progression, ascites formation, and metastasis.  Bankert RB, Balu-Iyer SV, Odunsi K, Shultz LD, Kelleher RJ Jr, Barnas JL, Simpson-Abelson M, Parsons R, Yokota SJ. PLoS One. 2011;6(9):e24420.  PMID: 21935406, PMCID: PMC3174163

Antitumor activity from antigen-specific CD8 T cells generated in vivo from genetically engineered human hematopoietic stem cells.  Vatakis DN, Koya RC, Nixon CC, Wei L, Kim SG, Avancena P, Bristol G, Baltimore D, Kohn DB, Ribas A, Radu CG, Galic Z, Zack JA.  Proc Natl Acad Sci U S A. 2011 Dec 20;108(51):E1408-16. Epub 2011 Nov 28.  PMID: 22123951

Myeloma-induced alloreactive T cells arising in myeloma-infiltrated bones include double-positive CD8+CD4+ T cells: evidence from myeloma-bearing mouse model.  Freeman LM, Lam A, Petcu E, Smith R, Salajegheh A, Diamond P, Zannettino A, Evdokiou A, Luff J, Wong PF, Khalil D, Waterhouse N, Vari F, Rice AM, Catley L, Hart DN, Vuckovic S.  J Immunol. 2011 Oct 15;187(8):3987-96. Epub 2011 Sep 9.
PMID: 21908738

Successful establishment of an orthotopic hepatoblastoma in vivo model in NOD/LtSz-scid IL2R_null mice.  Ellerkamp V, Armeanu-Ebinger S, Wenz J, Warmann SW, Schäfer J, Ruck P, Fuchs J.  PLoS One. 2011;6(8):e23419. Epub 2011 Aug 10.  PMID: 21853130

Humanized tumor mice-A new model to study and manipulate the immune response in advanced cancer therapy.  Wege AK, Ernst W, Eckl J, Frankenberger B, Vollmann-Zwerenz A, Manel DN, Ortmann O, Kroemer A, Brockhoff G. Int J Cancer. 2011 May 4. doi: 10.1002/ijc.26159. [Epub ahead of print]  PMID: 21544806